Lee Ho-young

Lee Ho-young is a Professor at Seoul National University, specializing in Pathophysiology. His research focuses on elucidating the mechanisms of lung diseases such as lung cancer and emphysema, with an emphasis on developing novel preventive and therapeutic strategies.

• Lung cancer and emphysema pathogenesis
• Role of insulin-like growth factor (IGF) signaling
• Drug resistance in anticancer therapies
• Natural product-based drug discovery

His lab employs genetically modified animal models to analyze interactions between lung stem cells, epithelial cells, and the microenvironment under stressors like smoking, fine dust, and chronic stress. Recent work includes studies on IGF2-mediated resistance to HDAC inhibitors and the development of low-toxicity dual inhibitors for IGF1R/Src pathways. Publications highlight translational approaches combining mechanistic research with clinical applicability.