معرفی
Ledong Wan is an Assistant Professor at the Department of Pharmacological Sciences within Renaissance School of Medicine and the Cancer Center at Stony Brook University. His research focuses on RNA alternative splicing dysregulation in cancer, particularly pancreatic cancer and colorectal cancer, using transgenic mouse models and organoid cultures. The lab also explores small molecules and antisense technology for modulating aberrant splicing to develop cancer therapies.
Research Interests: Dr. Wan’s work centers on understanding how RNA splicing becomes dysregulated in pancreatic and colorectal cancers, leading to tumor progression. His team investigates splicing factors like SRSF1 and SRSF6, their roles in inflammation, and therapeutic strategies targeting these mechanisms.
Trends in Publications: His recent articles highlight RNA splicing in pancreatic ductal adenocarcinoma, colorectal cancer, and thyroid cancer. Key themes include splicing factors (SRSF1, RBM10), organoid-based drug screening, chronic stress effects on metastasis, and antisense oligonucleotides for splicing modulation.
