معرفی
Leandro Soter is an Associate Professor in the Department of Organic Chemistry at the Federal University of Rio de Janeiro, Brazil. He was hosted as a fellow-in-residence at CY Advanced Studies (CY AS), invited by the BIOCIS laboratory, where he delivered a guest lecture on nucleos(t)ide-based drug design.
His research focuses on the development of nucleoside and nucleotide analogues for therapeutic applications. These compounds are strategically designed to interfere with key biological processes in cancer and viral infections, leveraging their structural similarity to natural biomolecules involved in genetic information transfer and cellular signaling.
The work highlights a strong trend in medicinal chemistry targeting antiviral and anticancer agents, particularly through the modification of privileged structures like ribavirin. Recent efforts have focused on enhancing molecular stability while preserving base-pair recognition capabilities, enabling novel substitution patterns with potential for broader pharmacological activity.
Leandro Soter has contributed to advancements in understanding how modified nucleos(t)ides can be optimized for clinical use, especially against diseases such as leukemia, gastric cancers, HIV, hepatitis B and C, and hemorrhagic fevers. His interdisciplinary approach integrates organic synthesis with biochemical evaluation.
He has been recognized as a speaker in international academic forums, including the guest lecture series at CY AS, and his talk is available on the CY AS YouTube channel. No specific awards, grants, or student advisement details were mentioned in the source text.
