Leah Shriver

Leah Shriver is a Research Associate Professor in the Department of Chemistry at Washington University in St. Louis, with an additional appointment in the Division of Nutritional Science and Obesity Medicine, Department of Medicine. She serves as Director for the Center for Proteomics, Metabolomics, and Isotope Tracing, leading cutting-edge research at the intersection of metabolism, disease, and regenerative medicine.

Her research focuses on metabolic coupling between cells, particularly in pathological contexts such as cancer, infection, and tissue injury. Using integrative approaches including metabolomics, single-cell RNA sequencing (scRNA-seq), and multiplexed protein imaging, Dr. Shriver investigates how metabolic exchange is disrupted in diseases like glioblastoma and viral infections. She also explores how stem cell metabolism can be manipulated to enhance tissue repair after injury.

The body of her work demonstrates a strong trend toward systems-level understanding of metabolic dysregulation in disease, leveraging multi-omics technologies to identify novel therapeutic targets in oncology, virology, and regenerative medicine.

• Research Associate Professor, Department of Chemistry
• Appointment in Division of Nutritional Science and Obesity Medicine, Department of Medicine
• Director, Center for Proteomics, Metabolomics, and Isotope Tracing

Dr. Shriver leads a multidisciplinary research program focused on uncovering metabolic drivers of pathology and developing targeted interventions. Her lab employs in vitro and in vivo models, including the cuprizone model of demyelination, to study stem cell function and tissue regeneration. While specific grants are not listed, her research scope implies support in areas of cancer metabolism, infectious disease, and metabolic imaging. She mentors research teams working across chemical biology, translational medicine, and systems biology.

She leads the Center for Proteomics, Metabolomics, and Isotope Tracing, which provides advanced technological infrastructure for metabolic flux analysis, biomolecular profiling, and isotope-based tracing in complex biological systems. This core facility supports collaborative research across disciplines, enabling high-resolution investigation of metabolic networks in health and disease.