معرفی
Laureline Berthelot serves as a Research Fellow at INSERM and leads the NEMO team (NEuroinflammation, Mechanisms and Therapeutic Options) within the Center for Research in Transplantation and Translational Immunology (CR2TI, UMR 1064) at the University of Nantes' Faculty of Medicine and Medical Techniques. She teaches Neuroimmunology in Master's programs including Nantes University's GP Master MICAS, University of Rennes' Master 2 Clinical Neurosciences, and Paris Cité University's Master 2 Epithelia Interface Structure.
Her academic trajectory includes:
- Doctorate in Biology, Immunology (2003-2007) from INSERM U643, Nantes
- Postdoctoral fellowship in Renal immunopathology (2007-2012) at INSERM U699, Paris
- Research Fellow CR2 INSERM (2012-2016) at Center for Research on Inflammation, Paris
- CR1 INSERM Research Fellow (2017-2021) at Center for Research in Transplantation and Immunology, Nantes
- Authorization to direct research (2017) from Paris-Diderot University
Dr. Berthelot's research centers on antibody-microbiota crosstalk in chronic inflammatory conditions, with particular emphasis on IgA/Fc receptor dynamics in multiple sclerosis, neuromyelitis optica, IgA nephropathy, and IgA vasculitis. Her work explores molecular mechanisms linking gut microbiome alterations to neuroinflammation and kidney pathology through the gut-brain and gut-kidney axes, utilizing translational approaches from molecular immunology to clinical studies.
Analysis of her 12 publications (2020-2024) reveals consistent investigation of microbiome-immune system interactions across neurological and renal diseases. Key patterns include characterization of microbiota-derived metabolites in MS pathogenesis, IgA1 posttranslational modifications in glomerulonephritis, and identification of microbial triggers like Akkermansia in autoimmune responses. Her work bridges immunology, microbiology, and clinical medicine with strong translational focus.
Scientific Awards:
- No awards listed in provided materials
As an HDR-qualified researcher, Dr. Berthelot supervises graduate students and leads research projects funded through INSERM mechanisms. Her NEMO team investigates therapeutic interventions targeting neuroinflammatory pathways, with current work focusing on IgA-microbiota crosstalk in MS progression and novel biomarker discovery.
Dr. Berthelot directs the NEMO team at CR2TI, employing multidisciplinary approaches including immunological assays, microbiome analysis, and clinical correlation studies. The team maintains active collaborations across French institutions (Nantes, Rennes, Paris) and investigates molecular pathways connecting mucosal immunity to central nervous system and kidney inflammation, with emphasis on developing targeted therapies for autoimmune conditions.
