Léon Reubsaet

Léon Reubsaet is a Professor in Pharmaceutical Analytical Chemistry at the University of Oslo's Department of Pharmacy. He holds a Master’s in Molecular Toxicology from Vrije Universiteit Amsterdam and a Ph.D. in Pharmaceutical Analysis from Utrecht University. Prior to academia, he worked in R&D at Nycomed Imaging AS and Amersham Pharmacia Biotech AS. His research focuses on innovative analytical methods for detecting peptides and proteins in biological samples, particularly using advanced sample preparation and LC-MS/MS techniques. Key contributions include developing 'smart samplers' for dried blood spots and integrating pretreatment into sampling devices to enhance low-abundance protein analysis.

Education:

• Master’s in Molecular Toxicology, Vrije Universiteit Amsterdam
• Ph.D. in Pharmaceutical Analysis, Utrecht University

Research Interests:

• Ultra-low concentration protein detection in complex matrices
• Smart blood spot sampling with integrated pretreatment
• Molecularly imprinted polymers and affinity capture methods

Articles Trends: Recent work emphasizes smart sampling technologies (e.g., Volumetric Absorptive Microsamplers, antibody-functionalized paper) and their validation for clinical applications. Key topics include proteolytic samplers, dried serum spot analysis, and improving LC-MS-based protein quantification precision.

Grants & Advising: Extensive collaborations with institutions like Caltech and Utrecht University, though specific grant details are not listed. Supervises researchers like Trine Grønhaug Halvorsen and Ago Mrsa in lab projects.

Labs/Teams: Leads the Pharmaceutical Analytical Chemistry group and the SmartProteinAnalysis@UiO initiative, focusing on advancing protein analysis methodologies.