Klazina Kooiman

Klazina Kooiman is an Associate Professor in the Department of Cardiology at Erasmus MC, where she leads research in ultrasound-mediated therapies, microbubble technology, and targeted drug delivery. Her work bridges biomedical engineering and clinical cardiology, focusing on innovative methods to enhance therapeutic efficacy using acoustic agents.

Her research interests center on microbubble dynamics, sonoporation, and contrast-enhanced ultrasound. She investigates how engineered microbubbles can be used to locally deliver drugs to endothelial tissues and tumors, leveraging ultrasound to trigger controlled permeabilization of cell membranes. Her lab employs advanced techniques such as confocal microscopy and acoustic characterization to study microbubble behavior under physiological conditions.

The recent publications highlight a strong focus on monodisperse microbubbles, phospholipid coatings, and ultrasound-responsive drug carriers. These studies span from fundamental physics of bubble oscillations to translational applications in cardiovascular disease and oncology, indicating a cohesive research trajectory aimed at clinical translation of acoustic therapeutics.

Kooiman has supervised multiple research projects, as indicated by her supervised work record. Though specific awards and grants are not listed, her consistent high-impact publications in journals like ACS Applied Materials and Interfaces and Journal of Controlled Release reflect recognition in her field. She collaborates extensively with experts in ultrasound physics, biomaterials, and cardiovascular biology.

Her research group is actively involved in developing next-generation ultrasound contrast agents and therapeutic microbubbles. The team explores both soft- and hard-shelled microbubble systems, aiming to optimize stability, targeting, and bioeffects for safe clinical application.