Keivan Golshiri

Keivan Golshiri is a researcher at Erasmus MC, Erasmus University Rotterdam, in the Department of Internal Medicine. His research focuses on vascular aging, phosphodiesterase signaling, and smooth muscle cell dysfunction, with an emphasis on pharmacological interventions to improve vascular function in aging models.

Research Interests: His work spans vascular biology, aging mechanisms, cyclic GMP metabolism, phosphodiesterase-1 (PDE1) inhibition, vasodilatation, and perivascular adipose tissue function. He investigates molecular and physiological changes in vascular smooth muscle cells during aging and explores therapeutic strategies targeting the cGMP pathway.

Publication Trends: Recent publications (2022–2024) highlight a strong focus on PDE1 inhibition, soluble guanylate cyclase activation, and adiponectin's role in vascular function. His research combines translational pharmacology with in vivo mouse models of accelerated aging, aiming to uncover novel therapeutic targets for age-related vascular diseases.

Scientific Contributions: Golshiri has contributed to several high-impact studies, including a doctoral thesis on PDE1 inhibitors and publications in Aging Cell, Frontiers in Pharmacology, and Vascular Pharmacology. His collaborative work with experts like A.J.M. Roks and A.H.J. Danser underscores his integration into a leading cardiovascular research group.

Advising and Grants: While no formal advisees or grant awards are listed, his role as a primary author on multiple peer-reviewed articles and his doctoral thesis suggest active involvement in research projects likely supported by institutional or national funding. He collaborates extensively within Erasmus MC and external partners in cardiovascular aging research.

Labs and Research Teams: He is part of a research team at Erasmus MC focused on vascular pharmacology and aging, working under or alongside senior investigators in the Department of Internal Medicine. The team utilizes transgenic mouse models, molecular pharmacology, and physiological assessments to study vascular dysfunction in aging.