Keith Brocklehurst

Professor Keith Brocklehurst is a faculty member at Queen Mary University of London, affiliated with the School of Biological and Behavioural Sciences. His research focuses on mechanism-targeted kinetic studies of enzymes and catalytic antibodies, employing stopped-flow kinetic, protein engineering, and computational techniques. Key interests include cysteine proteinase superfamily variations, inhibitor design, and the interplay between molecular recognition and catalytic site chemistry.

His work emphasizes structural and kinetic analysis of enzymes like papain and actinidin, alongside investigations into antibody-catalyzed reactions. Notable contributions include studies on phytopathogen pectin methylesterase activity and cobalamin biosynthetic pathways. Brocklehurst has authored multiple book chapters and handbook entries, including sections on affinity chromatography and catalytic antibody design.

Publications highlight his interdisciplinary approach, bridging biochemistry, enzymology, and immunology. His research explores topics such as antibody substrate selectivity, enzyme conformational isomers, and the impact of temperature on enzymatic reactions. Collaborations with groups like Gallacher’s lab underscore his expertise in antibody-catalyzed hydrolysis mechanisms.