معرفی
Kasturi Roy, PhD, is an Associate Research Scientist in the Department of Internal Medicine Nephrology at Yale School of Medicine, affiliated with the Somlo Laboratory. She holds a PhD in Biotechnology from the University of Calcutta (2014). Her research focuses on cilia biology, neuronal cotransporters (NKCC1/KCC2), and the molecular mechanisms underlying kidney diseases like polycystic kidney disease (PKD) and neurodegenerative disorders such as Alzheimer’s. Her work integrates structural biology, proteomics, and cellular signaling to understand lipid modifications, palmitoylation, and protein interactions in disease contexts.
Key research areas include the structural basis of ion transport inhibition by diuretics, cilia-dependent signaling pathways, and the role of Grb2 in cytoskeletal stability and autophagy. Dr. Roy collaborates with prominent researchers like Biff Forbush, Gary Rudnick, and Zhaoxia Sun, contributing to high-impact studies published in Cell, Nature Communications, and Journal of Biological Chemistry.
Her publications highlight advancements in serotonin transporter inhibitors, NKCC1 inhibition mechanisms, and the structural dynamics of neuronal transporters. Ongoing projects explore ciliary protein stability, PKD pathogenesis, and the interplay between receptor tyrosine kinases in metabolic and neurological disorders.
Dr. Roy’s work bridges basic science and translational medicine, with implications for developing targeted therapies for kidney diseases and neurodegenerative conditions. She is actively involved in the Somlo Laboratory, contributing to interdisciplinary teams studying cilia dysfunction and cystic disorders.
