معرفی
Julien Ayroles is an Assistant Professor of Ecology and Evolutionary Biology and a member of the Lewis-Sigler Institute for Integrative Genomics at Princeton University. He is affiliated with the High Meadows Environmental Institute (HMEI) as an Associated Faculty member. His research focuses on understanding how natural selection shapes genetic variation, reshapes genomic architecture, and generates adaptive phenotypes. Central to his work are investigations into the emergence of variation in co-regulated gene networks and their contribution to phenotypic diversity, with particular attention to context-dependent genetic effects influenced by genetic background and environmental factors.
Dr. Ayroles employs advanced genomic technologies and quantitative genetics to bridge evolutionary dynamics with molecular mechanisms. His lab uses model organisms like Drosophila melanogaster and studies human populations (e.g., the Turkana) to explore topics such as microbiome-host interactions, gene expression variability, and the evolutionary mismatch framework’s implications for health. His work integrates systems biology approaches, epistasis analysis, and computational modeling to address complex questions in evolutionary and ecological genetics.
Recent research highlights include studies on dietary stress adaptation, urbanization’s impact on cardiometabolic health in Indigenous populations, and the role of Wolbachia in microbiome diversity. His publications emphasize interdisciplinary methods, including stochastic block modeling for gene networks and longitudinal sequencing to dissect polygenic traits.
Dr. Ayroles leads the Ayroles Lab at Princeton (https://ayroleslab.princeton.edu/), fostering collaborative research at the interface of genetics, ecology, and human health. He holds a Ph.D. in Genetics (implied by his career trajectory) and has contributed to foundational work in quantitative genetics and systems biology.
