José Cohen

José Cohen is a Researcher and Head of the Immunoregulation and Biotherapy (I-BIOT) team at the Mondor Biomedical Research Institute (IMRB), part of Inserm U955. His research focuses on immune response modulation in allografts, cancer, and tumor microenvironment interactions. He leads experimental models in grafts (skin, HSC) and collaborates with clinical departments in nephrology, oncology, and hematology. He co-leads the clinical investigation center in biotherapy and coordinates the FHU 'TRUE' for immune disorder therapies. His team operates a mass spectrometry platform managed by José Courty, with expertise in animal models, immunohistochemistry, and tumor organoids. Recent work includes patents on immune checkpoint inhibitors and collaborations with pharmaceutical companies.

Research interests emphasize translating immunological discoveries into clinical biotherapies, particularly in graft-versus-host disease and tumor immunology. Key publications address Treg-targeted therapies, TNFR2 blockade, and epigenetic regulation in cancer immunity. He advises PhD students in immunology and biomedicine, fostering interdisciplinary projects to reduce animal testing and expand translational research.

Collaborations include the 'Focis center of excellence' in transplantation and cancer, integrating clinical trials and early-phase drug development. His team’s activities bridge basic science with clinical applications, focusing on personalized immune-based interventions for chronic diseases and cancer.