Josiah Passmore

Dr. Josiah Passmore is a Researcher in the Department of Cell Biology, Neurobiology and Biophysics within the Faculty of Science at Utrecht University. His work focuses on understanding cellular organization and organelle interactions through advanced microscopy techniques.

Dr. Passmore's primary research investigates the "organelle connectome" - the complex network of interactions between cellular organelles. He specializes in studying membrane contact sites, regions where organelle membranes come into close proximity, often tethered by proteins. These sites play crucial roles in metabolite exchange, lipid transfer, intracellular signaling, and coordinating organelle dynamics. His methodology includes inducible organelle transport systems that allow physical contact to persist during artificial organelle displacement, enabling him to probe the extent, regulation, and robustness of the organelle connectome.

Dr. Passmore's publication record reveals a significant evolution from fundamental studies of organelle biology toward the development of advanced microscopy techniques. His work on GelMap represents a major contribution to intrinsic calibration and deformation mapping in expansion microscopy. His research increasingly bridges computational approaches with biological questions, developing sophisticated methods for analyzing cellular structures and spatial organization. The progression from his 2021 review on organelle dynamics to his 2025 computational biology papers demonstrates a clear trajectory toward methodological innovation in cellular imaging.

His research contributes to UN Sustainable Development Goals related to scientific advancement and technological innovation. The fingerprint analysis of his work identifies key themes including Expansion Microscopy (100%), Deformation Mapping (66%), Intrinsic Calibration (66%), Hydrogel Engineering (50%), Organelle Interaction (33%), Organelle Dynamics (33%), Grid Deformation (33%), and Deformation Correction (33%).