Joshua Muia

Dr. Joshua Muia is an Associate Investigator at the Versiti Blood Research Institute and Assistant Professor in the Department of Biochemistry at the Medical College of Wisconsin. He holds dual affiliations in laboratory research and clinical hematology. His work focuses on metalloproteases (ADAMTS family) involved in cardiovascular disease, particularly ADAMTS13's role in thrombotic thrombocytopenic purpura (TTP) and von Willebrand factor (VWF) regulation.

Education:

• Postdoctoral Research Associate, Washington University School of Medicine
• Doctor of Philosophy, Western Michigan University

Research Interests:

• Structural-functional studies of ADAMTS13
• VWF pathophysiology in thrombotic/bleeding disorders
• Development of fluorogenic substrates for clinical enzyme assays
• Role of ADAMTS7 in coronary artery disease
• Protein-protein interaction techniques (BLI, SPR, co-IP)

Grant Support:

• NIGMS R35 GM142926: MIRA Award (2021-2026) investigating ADAMTS13/ADAMTS7 regulation

Laboratory Team:

• Constance Kwas - Senior Research Technologist
• Jeremy Mattson - Senior Research Technologist
• Thomas Momanyi - Graduate Student