معرفی
Jose S. Madalengoitia is an Associate Professor in the Department of Chemistry at the University of Vermont. His research focuses on synthetic and bioorganic chemistry, particularly the development of the 1,3-diaza-Claisen rearrangement and its applications in synthesizing complex molecules like guanidines and tricyclic compounds. His work integrates experimental synthesis with computational methods (DFT calculations) to understand reaction mechanisms and optimize pathways.
Education:
- Ph.D., University of Virginia, Charlottesville, VA (1993)
- Postdoctoral Fellowship, University of California, Irvine (1993-1995)
Research Interests:
Madalengoitia’s lab explores the 1,3-diaza-Claisen rearrangement, including its application to bridged bicyclic systems, tethered variants for tricyclic guanidine synthesis, and cationic rearrangement pathways. Current efforts aim to achieve diastereoselectivity, chirality transfer, and catalytic approaches for broader applicability. DFT calculations are central to guiding these studies and understanding reaction energetics.
Awards: None explicitly listed.
Advising/Grants: No specific grants or student advisees listed. The lab emphasizes collaborative research between synthesis and bioorganic chemistry, targeting natural product synthesis and proteomic studies.
Labs/Teams: Part of the UVM Chemistry Department’s organic and bioorganic research group, utilizing facilities like the UVM Chemistry NMR Instrumentation.
