معرفی
Joon Seok Park is an Assistant Professor at the University of Chicago, affiliated with the Department of Medicine-Hematology and Oncology. His research focuses on understanding how commensal gut microbes influence systemic immunity, particularly in the context of cancer immunotherapy and tumor microenvironment (TME) regulation.
- Education: Ph.D. in Immunology from Cornell University (2016); B.S. in Biochemistry from Yonsei University (2009).
- Postdoctoral Training: Harvard Medical School (2023-2024) and The Rockefeller University (2017).
Dr. Park’s lab investigates two primary research directions: (1) the signaling pathways by which gut microbes modulate immune cells in the TME, such as PD-L2/RGMb interactions, and (2) the role of microbial metabolites in shaping the TME’s metabolomic landscape. The lab employs gnotobiotic mouse models and metabolomic approaches to identify therapeutic targets for microbial-based cancer therapies.
His recent publications highlight collaborations with researchers like Conghui Yao and explore topics such as microbial metabolite signaling, immunometabolism in T cells, and overcoming immunotherapy resistance via microbiome manipulation. The lab is embedded within the University of Chicago’s multidisciplinary research ecosystem, including the Comprehensive Cancer Center and Duchossois Family Institute.
The lab’s work is supported by affiliations with the Department of Medicine-Hematology and Oncology and leverages advanced techniques in immunology and microbiome analysis. Research outcomes aim to engineer bacteria for therapeutic molecule production and develop targeted delivery strategies to the TME.
