معرفی
Dr. Jonathan Nowak, MD, PhD is an Assistant Professor of Pathology at Harvard Medical School and an active investigator at the Hale Family Center for Pancreatic Cancer Research. He holds dual clinical and research appointments at Brigham and Women’s Hospital and the Dana-Farber Cancer Institute, where he specializes in molecular and gastrointestinal pathology. He co-leads the Wolpin-Nowak laboratory, which focuses on high-resolution, tissue-based analysis of pancreatic and colorectal cancers.
- Weill Medical College of Cornell University – MD
- The Rockefeller University – PhD (Tri-Institutional MD-PhD Program)
- Brigham and Women’s Hospital – Pathology Residency
- Harvard Medical School/Brigham and Women’s Hospital – Fellowships in Anatomic, Clinical, and Molecular Genetic Pathology
Dr. Nowak's research centers on the molecular and spatial characterization of solid tumors, particularly pancreatic and colorectal cancers. His lab employs multiplexed immunofluorescence, digital image analysis, and machine learning to dissect the tumor microenvironment at single-cell resolution. They develop assays to quantify immune infiltrates, tumor differentiation states, cell cycle activity, and stromal composition, enabling large-scale, spatially resolved studies across resected, neoadjuvant-treated, and metastatic tumor cohorts. Their work bridges clinical pathology and translational research, supporting biomarker discovery and precision oncology.
The recent publications highlight a strong focus on tumor-immune interactions, molecular subtyping, and prognostic biomarker development in gastrointestinal cancers. Using both protein and RNA expression data from human specimens, the studies integrate machine learning with spatial pathology to uncover clinically relevant patterns in pancreatic and colorectal cancers. A recurring theme is the use of scalable, customizable tissue-based assays applicable to clinical trials and routine care.
Dr. Nowak contributes to major collaborative efforts in pancreatic cancer research and is instrumental in genomic and pathological analysis of patient specimens. He helps design and interpret next-generation sequencing assays for tumor profiling and leads a constitutional genetics service for hereditary cancer predisposition. While no formal advising list is provided, his leadership of a research laboratory implies mentorship of postdoctoral fellows and research staff.
The Wolpin-Nowak lab serves as a key pathology resource within the Hale Family Center, analyzing mouse models, organoids, xenografts, and clinical trial specimens to understand pancreatic cancer biology. They collaborate extensively with other research teams to correlate molecular findings with morphologic and clinical data.
