Jon A. Detterich

Jon A. Detterich, MD is a Clinical Professor at the University of Southern California, affiliated with Children’s Hospital Los Angeles. His research focuses on pediatric cardiology, blood rheology, and congenital heart disease, particularly Fontan circulation and sickle cell disease. He has contributed to studies on biomarkers, vascular dysfunction, and imaging techniques in congenital heart defects.

His work emphasizes translational research linking basic biophysical mechanisms (e.g., blood viscosity, nitric oxide dynamics) to clinical outcomes in high-risk pediatric populations. Key areas include: (1) Fontan-associated pathophysiology, (2) sickle cell disease vasculopathy, and (3) neurocognitive outcomes in congenital heart disease patients. Recent studies explore novel biomarkers, therapeutic interventions, and imaging protocols to improve long-term outcomes.

Publications span 20+ years, with emphasis on hemodynamic modeling, vascular physiology, and disease mechanisms. Collaborations include multi-center trials like the Single Ventricle Reconstruction Study (SVR III) examining neurodevelopmental outcomes. His research bridges clinical cardiology with bioengineering approaches to address unmet needs in pediatric cardiovascular care.