Joline Fan

Joline Fan, MD, MS is an Assistant Professor at the University of California, San Francisco (UCSF) in the Departments of Neurology (Division of Epilepsy) and Psychiatry & Behavioral Sciences. She is affiliated with the UCSF Weill Institute for Neurosciences, where she conducts cutting-edge research at the intersection of neurology, psychiatry, and neurotechnology.

Dr. Fan completed her education at prestigious institutions: B.S.E. in Chemical and Biological Engineering from Princeton University, M.S. in Bioengineering from Stanford University, and M.D. from UCSF. She furthered her training with a Neurology Residency and Epilepsy Fellowship at UCSF, establishing her expertise in clinical neurology and epilepsy management.

Her research program focuses on developing innovative neurostimulation technologies for neuropsychiatric disorders and exploring the complex relationship between sleep and epilepsy through multimodal neuroimaging. As an epileptologist, Dr. Fan specializes in invasive recording methods including intracranial responsive neurostimulation and stimulation mapping. She is pioneering personalized, non-invasive, low-intensity focused ultrasound methods for treating conditions like depression and epilepsy, bridging engineering approaches with clinical neuroscience.

Analysis of Dr. Fan's recent publications reveals a strong focus on intracranial neurophysiology, brain network mapping, and closed-loop neuromodulation systems. Her work integrates multiple disciplines including neurology, psychiatry, neuroengineering, and data science to develop personalized treatments for treatment-resistant depression, obsessive-compulsive disorder, and epilepsy. The research demonstrates increasing translational impact with growing clinical applications of neuromodulation technologies.

Dr. Fan has received significant recognition for her work:

• American Epilepsy Society (AES) 2022 Young Investigator Award
• University of California San Francisco 2024 Chen Scholar Award

Dr. Fan actively mentors residents, fellows, and UCSF students on research projects. Her research is supported by multiple significant grants including a Brain & Behavior Research Foundation NARSAD Young Investigator Grant for 'Mapping Corticolimbic Circuitry of Arousal Using Intracranial Electrophysiology' (2023-2025), an NIH/NINDS K23 award for 'Network dynamics of sleep-wake states in epilepsy' (2023-2027), and previously a Doris Duke Charitable Foundation Physician Scientist Fellowship (2021-2023).

Working within the UCSF Weill Institute for Neurosciences, Dr. Fan collaborates with multidisciplinary teams across neurology, psychiatry, neurosurgery, and engineering to advance understanding of brain circuitry and develop novel neuromodulation approaches for complex neuropsychiatric conditions.