John P. O'Doherty

John P. O'Doherty serves as the Fletcher Jones Professor of Decision Neuroscience within Caltech's Division of Humanities and Social Sciences, holding continuous faculty appointments since 2004 (Assistant Professor 2004-07, Associate Professor 2007-09, Professor 2009-present, Fletcher Jones Professor 2021-present). He previously directed the Caltech Brain Imaging Center (2013-17) and maintains affiliations with the T&C Chen Center for Social and Decision Neuroscience.

His educational background includes a B.A. from University of Dublin, Trinity College (1996) and D.Phil. from University of Oxford (2000). His research focuses on computational and neural mechanisms of reward-based learning and decision-making, employing fMRI, intracranial recordings, and mathematical modeling to investigate how the brain solves complex decision problems through evolutionarily conserved algorithms. Key areas include

• Reinforcement learning systems (model-based/model-free arbitration)
• Observational and social learning mechanisms
• Neural representation of value, risk, and uncertainty
• Computational phenotyping of mental disorders
• Temporal dynamics of goal persistence

Analysis of his 2023-2025 publications reveals dominant trends in computational psychiatry (problem gambling, autism traits), hierarchical decision-making, and neuroeconomic modeling of social behavior. His work consistently integrates cross-species computational frameworks with human neuroimaging to identify transdiagnostic mechanisms.

While specific awards beyond his endowed professorship aren't detailed, his leadership as Brain Imaging Center Director and prolific high-impact publications demonstrate significant recognition. Current advising includes graduate researcher Sneha Aenugu on goal-persistence projects, with administrative support from Mary A. Martin (mmartin@caltech.edu). His active research program continues to pioneer computational approaches to understanding decision pathologies.