معرفی
John N. Buchholz, PhD is a Professor and Vice Chair of the Pharmacology Division within the Basic Sciences department at Loma Linda University School of Medicine. With over three decades of academic service, he maintains an active research program focused on cerebrovascular physiology and pharmacology, particularly examining intracellular calcium signaling mechanisms in endothelium, smooth muscle cells, and vascular sympathetic neurons.
Dr. Buchholz's educational background includes a PhD (1989), MS (1984), and BS (1980), all from Loma Linda University. His teaching responsibilities encompass Neuropharmacology (PHRM 554), Cardiovascular & Renal Pharmacology (PHRM 564), and Advanced Physiology & Pathophysiology (PHSL 506).
- PhD, Loma Linda University (1989)
- MS, Loma Linda University (1984)
- BS, Loma Linda University (1980)
His research interests span cardiovascular and neurophysiology, with particular focus on intracellular calcium signaling, cerebrovascular function, and the impact of aging on vascular mechanisms. Recent work has increasingly examined the relationship between cerebrovascular function and Alzheimer's Disease, exploring how aging alters cerebrovascular endothelial GPCR and K+ channel function with divergent roles based on biological sex.
Analysis of Dr. Buchholz's publication record (64 total publications) reveals a consistent focus on vascular physiology with evolving emphasis from basic calcium signaling mechanisms to age-related cerebrovascular changes and their relationship to neurodegenerative conditions. His work spans molecular, cellular, and systems-level approaches, often employing animal models to examine developmental and aging processes.
Dr. Buchholz received the Bernard D Griggs, MD Enowed Pharmacology Award in 2022, recognizing his contributions to the field.
- Bernard D Griggs, MD Enowed Pharmacology Award (2022)
As an active mentor and committee member, Dr. Buchholz has served on numerous institutional committees including the Basic Sciences Administrative Team, Admissions Committee, Academic Review Committee, and Promotions Committee. His grant portfolio includes significant NIH funding, most notably as Co-Investigator on the current project 'Cerebrovascular Endothelial Function During Age-Related Development of Alzheimer's Disease' (2022-2027), and previously as Co-PD/PI on the 'Center for Brain Hemorrhage Research' (2014-2019).
Dr. Buchholz maintains active involvement in professional societies including the Associated Societies for Pharmacology and Experimental Therapeutics (ASPET) and the Society for Neuroscience (SFN), and has served on review committees including the American Heart Association Western States Affiliate Cardiovascular Sciences II.
