معرفی
John M Seubert serves as an Adjunct Associate Professor in the Department of Pharmacology at the University of Alberta's Faculty of Pharmacy and Pharmaceutical Sciences. His research program investigates cytochrome P450-derived metabolites of arachidonic acid, particularly epoxyeicosatrienoic acids (EETs), in cardiac protection and mitochondrial regulation.
His educational background includes:
- BSc Biology (Toxicology) and Psychology Minor, Simon Fraser University (1992)
- MSc Biology - Aquatic Toxicology, Simon Fraser University (1997)
- PhD Pharmacology and Toxicology, University of Western Ontario (2002)
Dr. Seubert's research focuses on two primary areas: (1) The cardioprotective mechanisms of EETs in ischemia-reperfusion injury, utilizing transgenic mouse models with elevated EET levels and cardiomyocyte experiments; (2) EET-mediated regulation of mitochondrial dynamics and energetics in cellular survival pathways. His laboratory employs techniques including murine cardiac injury models, mitochondrial function assays, and lipid mediator analysis.
Analysis of his recent publications reveals strong emphasis on translational cardioprotection, with recurring themes in EET pharmacology, mitochondrial integrity during stress, and therapeutic targeting of soluble epoxide hydrolase. His work bridges molecular cardiology with pharmacological intervention strategies.
Professional activities include teaching PHARM367 and PHARM566 courses, with laboratory operations based in the Katz Group Centre (Room 2-020M). Current research directions involve sEH inhibition strategies and mitochondrial protection pathways.
