معرفی
John D. Lueck, Ph.D. is an Associate Professor in both the Department of Pharmacology and Physiology and the Department of Neurology at the University of Rochester School of Medicine and Dentistry. His research focuses on the molecular genetics and experimental treatment of diseases resulting from nonsense mutations, with particular emphasis on cystic fibrosis and myotonic dystrophy type 1 (DM1).
Dr. Lueck's research interests span multiple disciplines including RNA biology, membrane biophysics, and genetic disease mechanisms. His laboratory investigates the therapeutic promise of engineered suppressor tRNAs for treatment of nonsense mutation-associated diseases. The Lueck Lab applies molecular and cellular biology approaches to understand the molecular underpinnings of genetic diseases and develop therapeutic interventions, with a strong focus on cystic fibrosis and myotonic dystrophy.
Analysis of Dr. Lueck's recent publications reveals a consistent research trajectory focused on nonsense mutation suppression technologies, particularly anticodon-engineered tRNAs (ACE-tRNAs) for cystic fibrosis treatment. His work spans from basic mechanisms of nonsense suppression to translational applications, with increasing emphasis on developing platform technologies applicable across multiple genetic disorders. The research demonstrates strong interdisciplinary collaboration across molecular biology, pharmacology, and physiology.
Dr. Lueck maintains an active research laboratory with multiple postdoctoral scholars, graduate students, and undergraduate researchers. Current lab members include postdoctoral fellows Christina S. Heil and Joseph Porter, and graduate students Lily Cisco, Katherine Edwards, Rhodalyn Essien, Jeffrey Gabell, Wooree Ko, and Matthew Sipple. His laboratory is affiliated with multiple research centers including the Center for RNA Biology, Center for Musculoskeletal Research, and Lung Biology and Disease Program.
