Johann Matschke

Johann Matschke is a junior research group leader at the Institute of Cell Biology (Tumor Research), University Hospital Essen, and part of the Medical Faculty of the University of Duisburg-Essen. He leads the research group 'Metabolism and Radiation Response,' focusing on metabolic reprogramming in cancer and its role in radioresistance. His work aims to identify metabolic vulnerabilities in cancer cells to improve radiotherapy outcomes.

Research Interests: His primary research areas include cancer metabolism, radiation oncology, radioresistance, oxidative stress, hypoxia, DNA repair, and precision medicine. He investigates how cancer cells adapt metabolically to environmental and therapeutic stressors to survive radiation, with a focus on lung cancer, pancreatic cancer, and medulloblastoma.

Recent Research Trends: Analysis of his recent publications reveals a strong focus on metabolic adaptations under hypoxia, the role of oncometabolites (e.g., D-2-HG), modulation of antioxidant defenses (e.g., glutathione), and targeting metabolic pathways like SLC25A1 and SLC25A10 to enhance radiosensitization. His work increasingly integrates computational modeling and systems biology to identify predictive biomarkers and therapeutic targets.

Scientific Awards:

• No scientific awards explicitly mentioned in the provided text.

Advising and Grants: Dr. Matschke actively supervises numerous doctoral students across medical and scientific disciplines. He is involved in multiple funded research projects, including DFG-GRK 2762, BMBF NeuSTaRT, EU Horizon THERADNET, and DKTK, indicating sustained grant support and leadership in collaborative research.

Labs and Teams: He leads the 'Metabolism and Radiation Response' junior research group, employing techniques such as Seahorse Bioanalyser for real-time metabolic flux analysis, metabolome profiling, and radiobiological assays. His team collaborates nationally and internationally, including with institutions in Israel and Hamburg.