معرفی
Joel Brown, PhD, is a Research Professor at the University of South Florida's Moffitt Cancer Center, serving within the Integrated Mathematical Oncology program and the Cancer Biology & Evolution Program. His mission is to apply ecological and evolutionary principles to cancer treatment, aiming to improve patient survival and quality of life. He collaborates extensively with clinicians, mathematicians, and experimentalists to bridge theoretical models and clinical applications.
Education:
- PhD in Ecology and Evolutionary Biology, University of Arizona
Research Interests:
Brown's work is inherently multidisciplinary, integrating mathematical modeling, experimental oncology, and clinical trials. His primary focus includes:
- Adaptive therapy strategies for metastatic cancers (e.g., prostate, thyroid)
- Evolutionary dynamics of therapeutic resistance
- Ecological principles in tumor microenvironments
- Polyaneuploid cancer cell states and evolvability
- Game theory applications in cancer treatment optimization
Collaborations & Clinical Impact:
He partners with Drs. Robert Gatenby, Sandy Alexander, Ken Tsai, and Christine Chung on projects ranging from skin cancer cell culturing to Phase II trials for metastatic thyroid cancer. His models have informed adaptive therapy protocols, extending patient responses to treatments like abiraterone in prostate cancer.
Grants & Funding:
- Florida Breast Cancer Foundation: Effects of anesthetic agents on immune function and breast cancer progression (PI)
- Johns Hopkins University: Polyaneuploid cancer cell states and multitherapy resistance (PI)
- Florida Department of Health: Pediatric and AYA Evolutionary Tumor Board (Co-PI)
- National Cancer Institute: Eco-evolutionary drivers of clonal dynamics in UV-induced skin carcinogenesis (Co-PI)
Labs & Teams:
Brown is affiliated with the Cancer Biology & Evolution Group and Melanoma & Skin Cancer Center of Excellence at Moffitt. His team employs both computational and wet-lab approaches, fostering cross-disciplinary training through initiatives like the High School Internship Program in Integrated Mathematical Oncology (HIP IMO).
