Jingxuan He

Jingxuan He is an Assistant Research Professor in the Department of Chemistry at Pennsylvania State University. His research focuses on protein-protein interactions, metabolic channeling, and the structural biology of purinosome complexes. His work integrates biochemical assays, genetic engineering, and advanced proteomic techniques to explore enzyme co-localization and pathway regulation in metabolic networks.

Key research themes include:

• Purinosome formation mechanisms
• Metabolic channeling dynamics in de novo purine biosynthesis
• Unnatural amino acid incorporation in Streptomyces venezuelae for protein engineering

Recent publications reveal interdisciplinary efforts in:

• Photocrosslinking-based protein interaction mapping
• Post-translational modification impacts on enzyme activity
• Genomic analysis of antibiotic-producing actinomycetes

Affiliated with the Benkovic Research Group, his work bridges fundamental biochemistry with applications in synthetic biology and metabolic engineering.