Jimena Giudice

Jimena Giudice, PhD, is an Associate Professor and co-Director of Graduate Studies in the Department of Cell Biology and Physiology at the University of North Carolina at Chapel Hill. Her research focuses on alternative splicing mechanisms and their roles in membrane trafficking, muscle physiology, and disease. She is affiliated with the McAllister Heart Institute, the Curriculum in Cell Biology and Physiology, and the Curriculum in Genetics and Molecular Biology.

Educational Background:

• M.Ed. comparable in Chemistry Education, University of Buenos Aires (2001–2005)
• M.Sc. comparable in Chemistry, University of Buenos Aires (2002–2007)
• Ph.D. in Biological Chemistry, University of Buenos Aires (2007–2011)
• Postdoctoral training at Baylor College of Medicine (2011–2016)

Research Interests:

Dr. Giudice investigates how alternative splicing regulates membrane trafficking proteins in striated muscles and brain. Her lab uses molecular, cellular, and physiological approaches, including animal models, to study splicing's role in cell architecture and disease. Key areas include the crosstalk between alternative splicing and membrane dynamics in muscle development, with implications for disorders like muscular dystrophy and cancer metastasis.

Publications:

Her recent work includes studies on splicing regulation in biomolecular condensates, RBFOX2-driven transcription in myogenesis, and the role of SNORD67 in cancer metastasis. These highlight her focus on translating splicing mechanisms into therapeutic strategies.

Awards & Grants:

• Basil O’Connor Starter Scholar Award (2018–2020)
• NC TraCS Pilot Grant ($50K)
• Junior Faculty Development Award (2017)
• Pew Charitable Trusts Postdoctoral Fellowship (2012–2016)

Labs & Teams:

Her lab collaborates on interdisciplinary projects, leveraging expertise in RNA biology, muscle physiology, and cancer research. Key partners include the McAllister Heart Institute and the UNC Lineberger Comprehensive Cancer Center.