Jens Bukh

Jens Bukh is a Professor in the Department of Immunology and Microbiology at the University of Copenhagen's Faculty of Health and Medical Sciences, specializing in Virology. His research is centered around the Copenhagen Hepatitis C Program (CO-HEP), focusing on basic studies of the hepatitis C virus life cycle with important clinical implications for developing better therapies and vaccines that address the global health burden affecting over 150 million people worldwide.

Professor Bukh's research spans hepatitis C virus pathogenesis, viral evolution, antibody responses, and vaccine development. His work examines how hepatitis C virus evolves within hosts under immune pressure, particularly focusing on the hypervariable region 1 and its role in antibody evasion. He has expanded his research to include related hepaciviruses like the Norway rat hepacivirus as model systems, and more recently into SARS-CoV-2 cellular mechanisms. His laboratory investigates molecular mechanisms of viral persistence with the goal of informing therapeutic and vaccine development.

Analysis of Professor Bukh's recent publications reveals a strong focus on viral immunity and evolution. His research examines cross-reactive neutralization, T cell responses, and viral escape mechanisms. He employs both in vitro and in vivo model systems, with significant work on the Norway rat hepacivirus as a valuable model for understanding hepatitis C virus biology. His collaborative work spans multiple institutions and leverages advanced techniques in virology and immunology.

Professor Bukh leads the Copenhagen Hepatitis C Program (CO-HEP), which conducts fundamental research with direct clinical applications. His laboratory maintains active collaborations with clinical researchers and utilizes both human samples and animal models to advance understanding of hepacivirus biology. The program aims to contribute directly to the global effort to combat hepatitis C through improved understanding of viral pathogenesis and the development of more effective therapeutic and preventive strategies.