معرفی
Jennifer Kohler is an Associate Professor in the Department of Biochemistry at UT Southwestern Medical Center, leading the Kohler Lab. Her research focuses on developing chemical biology tools to study glycosylation's roles in biological systems, including glycans' interactions with pathogens like cholera toxin and their impact on cellular processes. She completed her Ph.D. at Yale University and postdoctoral training at UC Berkeley.
Key research areas include O-GlcNAc modifications, sialic acid pathways, and the structural biology of glycoconjugates. Her lab has pioneered photocrosslinking sugar analogs to study transient glycan-mediated interactions, advancing understanding of cholera toxin mechanisms and nuclear transport. Collaborations span glycobiology, infectious disease, and metabolic disorders.
Her work bridges biochemistry and clinical applications, with a focus on glycoscience's underappreciated potential in medicine and biotechnology. Current projects address glycosylation's role in intestinal epithelial biology and glycobiology tools' application to cancer and metabolic disorders.
Publications highlight discoveries in cholera toxin receptor dynamics, O-GlcNAc signaling, and glycan engineering. The lab is part of the Simmons Cancer Center, integrating glycoscience with oncology research.
