Jennifer Guler

Jennifer Guler is an Assistant Professor in the Department of Biology at the University of Virginia, where she leads the Guler Malaria Lab. Her research focuses on addressing the global challenge of antimalarial resistance in Plasmodium falciparum. The lab operates across three interconnected domains: investigating genomic mechanisms of drug resistance initiation, profiling metabolic adaptations in resistant parasites, and developing novel molecular surveillance tools for malaria-endemic regions.

Her research interests center on:

• Molecular mechanisms driving copy number variations and genome amplification in parasites
• Metabolic reprogramming during antimalarial resistance development
• High-throughput diagnostics for tracking resistance-conferring mutations
• Field-deployable genotyping tools for global surveillance
• Parasite evolution under drug selection pressure

Analysis of her 15 most recent publications reveals strong emphasis on:

• Advanced genomic technologies (long-read sequencing, single-cell analysis)
• Innovative molecular diagnostics (ddPCR, TaqMan arrays)
• Metabolic modeling and systems biology approaches
• Field applications in malaria-endemic regions (Thailand, Mozambique, South Africa)

The Guler Malaria Lab maintains a strong commitment to diversity and inclusion, actively fostering opportunities for underrepresented groups in STEM and promoting collaborative research with endemic countries to address global health disparities.