Jena Steinle

Jena Steinle is a Professor at Wayne State University's School of Medicine, affiliated with the Department of Ophthalmology and Visual Sciences. Her work focuses on cellular pathways involved in retinal damage due to diabetes, particularly HMGB1 and TLR4 signaling in inflammation, and PKA/Epac1 as upstream regulators. She employs protein biology, cell culture, and animal models in her research.

Education:

• PhD in University of Kansas Medical Center (2001)
• Post-Doc in Vascular Biology, Texas A&M University (2003)
• BS in University of Bridgeport (1997)

Research Interests center on diabetic retinopathy and ocular inflammation. Current projects include:

• Inhibition of HMGB1 as a protective mechanism against diabetic retinopathy
• PKA and Epac1 regulation of TLR4 in diabetic retina
• Insulin resistance mechanisms in diabetic retinas

Her work identifies novel therapeutic targets like glycyrrhizin and compound 49b, which restore retinal structure and reduce inflammation.

Article Trends highlight collaborations with labs in retinal vascular biology, focusing on inflammatory pathways (TLR4, NLRP3), HMGB1's role, and Epac1/PKA signaling. Techniques span miRNA analysis, protein regulation, and mouse/rat models.