معرفی
Jeffrey Dickhout is an Adjunct Lecturer in Medicine at McMaster University, with a research focus on endoplasmic reticulum (ER) stress and its role in cardiovascular and renal diseases. His work spans hypertension, chronic kidney disease (CKD), atherosclerosis, and pulmonary fibrosis, utilizing animal models like Dahl salt-sensitive rats and spontaneously hypertensive rats (SHR).
- ER stress in hypertension and CKD pathogenesis
- Chemical chaperone therapy (e.g., 4-phenylbutyrate)
- TGF-β and SREBP signaling in fibrosis
- Vascular remodeling and myogenic constriction
Recent studies (2024) explore follistatin's antihypertensive effects and PCSK9 antibodies' role in renal lipotoxicity. Over 30 peer-reviewed publications since 2000 address ER stress, atherosclerosis, and macrophage differentiation. Teaching includes Introduction to Pharmacology (PHARMAC 3A06A/B, 2017-2025).
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