Jeff Bronstein

Jeff Bronstein, MD, PhD is a Professor of Neurology at the David Geffen School of Medicine at UCLA and holder of the Fred Silton Family Chair in Movement Disorders. His research focuses on the interplay between environmental exposures and genetic susceptibility in Parkinson's disease, with particular emphasis on pesticide effects, air pollution, and epigenetic mechanisms.

• Current Principal Investigator for NIH grants R21ES016446 and R01NS035861
• Specializes in zebrafish models of neurodegeneration and human iPSC neuron screening

Research trends from 2022-2025 show consistent focus on:

• Environmental neurotoxicity (pesticides, air pollution, heavy metals)
• Epigenetic mechanisms in Parkinson's disease
• Gut-brain axis and microbiome associations
• Genetic risk factors and polygenic interactions
• Autophagy and proteasome dysfunction

Key contributions include:

• Development of zebrafish models for pesticide neurotoxicity
• Identification of lysosomal gene-environment interactions
• Advancements in extracellular vesicle biomarkers for synucleinopathies
• Guidelines for Wilson disease management
• Deep brain stimulation outcomes research