Janina Kupke

Janina Kupke is a Researcher at the Vrije Universiteit Amsterdam, affiliated with the Faculty of Science's Molecular and Cellular Neurobiology department and Amsterdam Neuroscience's research groups (Cellular & Molecular Mechanisms and Mood/Anxiety/Psychosis/Stress/Sleep). Her work focuses on molecular mechanisms underlying memory formation, epigenetic regulation (DNA methylation/DNA damage), neuronal plasticity, and aging effects on cognitive functions. Key research areas include hippocampal function in fear memory, systems consolidation, and age-related memory impairments.

Her research outputs (12 articles) emphasize interdisciplinary approaches combining molecular biology, neuroscience, and genetics. Notable contributions include studies on Dnmt3a1's role in fear memory via Nrp1, Npas4's biphasic regulation of fear inhibition, and Gadd45 proteins' impact on neuronal plasticity. She also investigates aging-related cognitive decline through engram stability and stem cell quiescence mechanisms.

Leveraging mouse models, her work bridges basic neurobiology with translational insights into neurodegenerative and psychiatric disorders. Collaborations span institutions globally, with active participation in high-impact journals like Neuropsychopharmacology and Molecular Psychiatry.