معرفی
Jan-Olov Höög is a Senior Professor in the Department of Medical Biochemistry and Biophysics at Karolinska Institutet. His research focuses on the structure, function, and evolution of alcohol dehydrogenases (ADH) and related enzymes, particularly their roles in metabolism, toxicology, and disease. He has held academic positions since 1988, including a Docent degree from Karolinska Institutet. His work integrates computational biology, enzymology, and molecular genetics to explore enzyme mechanisms and their implications in health and disease.
Education and Career:
- Docent (1988), Karolinska Institutet
- Professor (2001–2024), Department of Medical Biochemistry and Biophysics
- Senior Professor (2025–present), Department of Medical Biochemistry and Biophysics
Research Interests:
Dr. Höög's studies center on ADH enzymes, including their substrate specificity, catalytic mechanisms, and evolutionary diversity. Key themes include:
- Enzymatic roles in alcohol and retinol metabolism
- Molecular mechanisms of S-nitrosoglutathione reduction
- Comparative analysis of mammalian ADH genes and proteins
- Applications in toxicology and drug design
Publications:
His research spans over three decades, with a focus on enzyme structure-function relationships and their biomedical relevance. Recent work includes computational studies of ADH variants and investigations into enzyme inhibition mechanisms.
Grants and Collaborations:
His work has been supported by grants focusing on enzyme biology and toxicology. Collaborations include studies with researchers in bioinformatics and cell biology to explore enzyme regulation in carcinogenesis.
Labs/Teams:
He leads a research team specializing in enzymology and molecular biology within the Department of Medical Biochemistry and Biophysics.
