معرفی
Jan Böhning is a Junior Research Fellow and MRC Career Development Fellow at the MRC Laboratory of Molecular Biology, University of Cambridge, where he investigates tuberculosis persistence mechanisms using structural and infection biology approaches.
Education:
- Biochemistry studies at Universities of Bayreuth and Munich (Germany) with research at UC San Diego
- Doctorate at University of Oxford on structural analysis of bacterial multicellular assemblies in chronic infections
His research centers on Mycobacterium tuberculosis cell envelope integrity, focusing on how membrane transporter complexes enable nutrient uptake while blocking antibiotics. He extends this work to bacterial biofilms, examining phage-mediated antibiotic tolerance and matrix molecule architecture through cryo-EM and infection models. This integrated approach aims to identify novel drug targets against persistent infections.
Analysis of his 2021-2025 publications reveals dominant themes in cryo-EM structural studies of bacterial pathogens, particularly tuberculosis efflux systems and Pseudomonas biofilm architecture. His work combines advanced imaging with biophysical analyses to elucidate antibiotic resistance mechanisms, while methodological innovations in sample preparation enhance structural resolution for complex protein assemblies.
Based at the MRC LMB, Böhning leverages his Career Development Fellowship to bridge structural insights with infection biology, contributing to interdisciplinary efforts against antimicrobial resistance within Cambridge's world-leading research ecosystem.
