Ivan Sadowski

Ivan Sadowski is a Professor in the Department of Biochemistry & Molecular Biology at the University of British Columbia's Faculty of Medicine. His research focuses on signal-responsive gene regulation in human T cells and Saccharomyces cerevisiae, particularly mechanisms linking HIV-1 latency, cancer signaling, and CDK8 kinase function.

• Education: BSc (Microbiology) - University of Saskatchewan, 1982; MSc (Microbiology) - University of Manitoba, 1984; PhD (Medical Genetics) - University of Toronto, 1987; NCIC Postdoctoral Fellowship - Harvard University, 1987

Research Highlights: Key contributions include discovering CDK8's role in integrating physiological signals with transcriptional responses, identifying RBF-2 (USF1/USF2/TFII-I) in HIV latency control, and developing the Red-Green HIV reporter system for studying integration dynamics. His work bridges fundamental eukaryotic gene regulation with translational HIV research.

Publications Trends: Recent studies emphasize TRIM24 interactions with HIV latency, PhosphoGRID database curation, and small molecule screens for latency reversal. The 2013-2024 outputs show consistent focus on transcription factor phosphorylation, chromatin organization, and therapeutic targeting of latent reservoirs.