معرفی
Isaac Krauss is a Professor of Chemistry at Brandeis University, leading research in organic synthesis and chemical biology. His work focuses on developing synthetic methods for complex molecules and applying directed evolution techniques to design HIV vaccine candidates. Krauss earned his Ph.D. from Columbia University and conducted postdoctoral research at Memorial Sloan-Kettering Cancer Center.
Educational Background
B.A. in Chemistry from Stanford University (1998)
Ph.D. in Chemistry from Columbia University (2003), advised by James Leighton.
Postdoctoral studies under Samuel J. Danishefsky at Memorial Sloan-Kettering Cancer Center (2004–2008).
Research Interests
Krauss' lab employs SELMA (SELection with Modified Aptamers) to engineer glycopeptide vaccines targeting HIV antibodies like 2G12. His organic synthesis projects include homoallylation and homocrotylation reactions for tetrahydrofuran/tetrahydropyran frameworks. Key themes include HIV vaccine design, carbohydrate chemistry, and enzyme-catalyzed mechanisms.
Publications & Impact
Over 40 peer-reviewed articles, including work in J. Am. Chem. Soc., Angew. Chem. Int. Ed., and ACS Central Science. Recent studies address glycan stability in vaccines and antibody specificity.
Awards & Grants
NSF CAREER Award (2013), Thieme Chemistry Journal Award (2013), and NIH grants totaling over $5M. Active projects include R21-AI174956 (HIV immunogens) and R01-GM127920 (glycosaminoglycan mimetics).
Teaching & Service
Teaches undergraduate and graduate organic chemistry courses. Served as Graduate Admissions Chair and on university-wide committees. Reviews for high-impact journals like Nature Chemical Biology and ACS Catalysis.
Labs & Collaborations
Krauss collaborates with institutions like the NIH and Merck. His lab emphasizes interdisciplinary approaches, combining chemistry with immunology and enzymology.
