Irene Retmana

Dr. I.A. (Irene) Retmana is a PhD Candidate at the Faculty of Science, Pharmacology department of Utrecht University. Her research focuses on pharmacokinetics and bioanalysis of covalent kinase inhibitors, particularly KRASG12C inhibitors like adagrasib, sotorasib, and opnurasib.

Key research areas:

• Validation of LC-MS/MS and HPLC-MS/MS methods for drug quantification
• Role of CYP3A enzymes and ABCB1 transporters in drug metabolism
• Biotransformation of targeted covalent kinase inhibitors in murine models

Publication trends:

• Development of chromatographic bioanalytical assays (2021-2024)
• Pharmacokinetic studies on KRASG12C inhibitors (2021-2023)
• Thesis work on LC-MS/MS bioanalysis and drug metabolism (2024)