معرفی
Igor Astsaturov, MD, PhD, is an Associate Professor in the Department of Hematology/Oncology at Fox Chase Cancer Center, where he also serves as Co-Director of the Marvin & Concetta Greenberg Pancreatic Cancer Institute and holds the inaugural Paul F. Engstrom Professorship in Oncology. His work integrates clinical oncology with fundamental research in cancer metabolism and signaling.
- Associate Professor, Department of Hematology/Oncology
- Co-Director, Marvin & Concetta Greenberg Pancreatic Cancer Institute
- Inaugural Holder, Paul F. Engstrom Professorship in Oncology
- Member, Cancer Signaling and Microenvironment Program
- Affiliated with Center for Immunology
Dr. Astsaturov's research focuses on the intersection of cancer metabolism and signaling, particularly the role of sterol metabolism in regulating tumor growth and response to therapy. His work has revealed critical links between cholesterol biosynthesis and EGFR inhibitor resistance in KRAS-driven cancers. He investigates pancreatic cancer biology and develops 'smart drugs' using patient-derived avatar models and genetically engineered systems to translate findings into clinical applications.
His recent publications span translational research, molecular oncology, and health disparities, with major contributions in Cancer Cell, Cell Reports, and Cancer Discovery. Themes across his work include metabolic vulnerabilities in cancer, tumor-stroma interactions, and precision medicine approaches for gastrointestinal malignancies.
- Philadelphia Magazine Top Doctors (2023–24)
- Paul F. Engstrom Professorship in Oncology (2023)
- Training Award, International Union Against Cancer
- Scholar-in-Training Award, AACR-OSI
- Sol Sherry Research Award, Temple University
- Fox Chase-Genentech Scholar
Dr. Astsaturov mentors a dynamic research team including postdoctoral fellows, graduate students, and technicians. His lab investigates mechanisms of resistance to anti-EGFR agents and explores novel therapeutic strategies targeting metabolic pathways. He has been involved in multiple NIH-funded projects and clinical trials, and actively advocates for increased research funding, notably through participation in national pancreatic cancer advocacy initiatives.
His laboratory collaborates extensively, particularly with Dr. Edna Cukierman, to study cancer-associated fibroblasts and their role in providing lipids to tumor cells. This work aims to disrupt CAF-cancer cell interactions and identify new treatment strategies for pancreatic cancer.
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