Hyungjin Eoh

Hyungjin Eoh is an Associate Professor at the Keck School of Medicine, University of Southern California, in the Department of Molecular Microbiology & Immunology. He earned his DVM from Seoul National University, Ph.D. from Colorado State University, and completed postdoctoral training at Weill Cornell Medical School. Since establishing his lab at USC in 2015, Dr. Eoh has pioneered metabolomics platforms to study Mycobacterium tuberculosis (Mtb) adaptive metabolism, aiming to discover novel antibiotics and diagnostics.

• Education: DVM (Seoul National University), Ph.D. (Colorado State University), Postdoc (Weill Cornell)
• Current research spans tuberculosis drug resistance, host-pathogen metabolic crosstalk, neurodegenerative disease metabolomics, viral metabolism hijacking (KSHV, HBV), and fatty liver disease.

His work reveals Mtb's metabolic strategies for drug tolerance, including trehalose catalytic shifts, phosphoenolpyruvate depletion, and proline/glutamate-mediated detoxification. Collaborative studies extend to ALS/Alzheimer's lipid metabolism, NTM infections, and HBV-induced macrophage reprogramming. Recent publications highlight mitochondrial NOTCH stabilization in cancer, trehalose pathway inhibitors, and oxidative stress-glucose metabolism interactions.

• Lab members include 6 graduate students/research associates, 4 undergraduates, and a Ph.D. lab manager.
• Key techniques: CRISPRi gene editing, multi-omics analysis, and metabolic profiling.