معرفی
Dr. Hongxin Dong is a Professor in the Department of Psychiatry and Behavioral Sciences at Northwestern University's Feinberg School of Medicine, with additional appointments in Neurology through the Ken and Ruth Davee Department. His laboratory has maintained a continuous research program since 2000 focusing on genetic and environmental influences on neurodevelopment and aging, particularly their relevance to Alzheimer's disease and related neuropsychiatric disorders.
Dr. Dong holds key affiliations with the Mesulam Center for Cognitive Neurology and Alzheimer's Disease, the Center for Autism and Neurodevelopment, the Northwestern University Clinical and Translational Sciences Institute (NUCATS), the Simpson Querrey Institute for Epigenetics, and the Stephen M. Stahl Center for Psychiatric Neuroscience. His research integrates clinical data from human antemortem assessments and postmortem tissues with animal models to discover novel molecular, genetic, and epigenetic mechanisms underlying neuropsychiatric symptoms in Alzheimer's disease.
Dr. Dong's research program is currently supported by multiple NIH grants including R01AG062249 (Molecular Mechanisms Underlying Behavioral and Psychological Symptoms in Alzheimer's Disease), R01AG079989 (Epigenetic Regulation in Aging and Alzheimer's Disease), and R01AG078386 (Estrogen signaling linked to stress and Alzheimer's Disease). His work has established important connections between stress, aging, and Alzheimer's disease pathogenesis, with particular focus on sex differences that may explain women's greater vulnerability to Alzheimer's disease.
Dr. Dong serves as Associate Editor for both the American Journal of Neurodegenerative Disease (since 2012) and the Journal of Alzheimer's Disease (since 2010), and previously served as Guest Editor for Neurobiology of Stress (2016-2017). He has received recognition including a Travel Award from the RNA Binding Proteins in Neurological Disease Symposia (2011).
His laboratory has produced over 85 publications spanning from 1997 to 2025, with recent work focusing on epigenetic mechanisms in Alzheimer's disease, sex differences in stress responses, behavioral and psychological symptoms of dementia, and novel therapeutic approaches targeting molecular pathways involved in neurodegeneration. His research has significant implications for developing new therapeutic strategies to slow disease onset and prevent progression of Alzheimer's disease and related disorders.
