معرفی
Hongkuan Fan is a Professor in the Department of Pathology and Laboratory Medicine at the Medical University of South Carolina (MUSC). His research focuses on vascular dysfunction in sepsis and neurovascular mechanisms in Alzheimer's disease, with particular emphasis on pericyte biology and long noncoding RNA regulation. He holds a PhD from Jilin University, China, and completed postdoctoral training at New Mexico Tech and MUSC.
Education:
- PhD, Jilin University, China, 2001
- Postdoctoral Training: New Mexico Tech, USA, 2001-2002
- Postdoctoral Training: Medical University of South Carolina, USA, 2002-2006
Research Interests:
- Role of pericytes in sepsis-induced vascular dysfunction and multi-organ failure
- Neurovascular unit dysfunction in Alzheimer's disease progression
- Mechanisms of lncRNA Neat1/Hbb axis in age-related cognitive decline
- Development of novel treatments targeting endothelial barrier integrity
Funding:
- R35 GM149203-01: Pericyte Role in Sepsis Vascular Dysfunction
- 1R01AG081807-01: Brain Hypoperfusion in Alzheimer's Development
Article Trends: Recent work emphasizes extracellular vesicle roles in sepsis outcomes, miRNA regulation of pericyte function, and neurodegenerative disease mechanisms involving lncRNAs. Key contributions include identifying Fli-1 transcription factor pathways and exosome-based therapeutic strategies.
