معرفی
Holger Grohganz is an Associate Professor in the Department of Pharmacy at the Faculty of Pharmaceutical Sciences, University of Copenhagen, holding this position since May 2011. His academic journey spans multiple Nordic institutions, including prior appointments at Nord-Trøndelag University College and the University of Tromsø.
His educational background includes:
- Ph.D. in Pharmacy, University of Tromsø (2004)
- Pharmacy degree, University of Erlangen-Nürnberg (1997)
- Registration as pharmacist (1998)
Dr. Grohganz's research centers on stabilizing unstable pharmaceutical compounds, addressing critical challenges in drug development: structural instability of macromolecules and poor water solubility of small molecules. His work pioneers co-amorphous systems to enhance drug solubility while maintaining stability, alongside advancing freeze-drying techniques for protein therapeutics. Key methodologies include multivariate analysis and design of experiments for pharmaceutical process optimization.
- Co-amorphous drug formulations
- Freeze-drying and spray-drying of biologics
- Design of experiments (DoE) implementation
- Process analytical technology (PAT)
His 2024-2025 publications reveal intensive focus on co-amorphous system stability under mechanical stress, crystallization mechanisms in hydrated systems, and novel electrospinning applications for drug delivery. Recent work extends to microfluidic liposome fabrication and inflammatory skin disease therapies using sustained-release dressings.
Dr. Grohganz actively supervises Master's theses in Pharmacy and teaches core courses including 'Pharmacy 2 - Solid Dosage Forms' and 'Bachelor Project in Pharmacy,' emphasizing production, composition, and quality assurance of tablets and solid formulations.
He leads research within the Solid State Pharmaceutics group at the University of Copenhagen, collaborating internationally on pharmaceutical development projects with emphasis on quality-by-design principles and advanced material characterization.
