Haojie Lu

Haojie Lu is a Researcher in the Department of Epidemiology at Erasmus MC, specializing in genetic epidemiology with focus on genome-wide association studies and Mendelian randomization. Affiliated with the School of Medicine, Lu contributes to major international consortia in cardiovascular and skeletal genetics research.

• Erasmus MC, School of Medicine, Department of Epidemiology

Lu's research centers on genetic determinants of complex traits including bone mineral density, coronary artery calcification, and facial morphology. The work integrates statistical genetics with clinical epidemiology to identify causal relationships and druggable pathways. Key methodological approaches include multi-ancestry GWAS, variance component analysis, and causal inference techniques.

Recent publications demonstrate consistent focus on cardiovascular-skeletal crosstalk and facial phenomics. The 2023 Nature Genetics paper on coronary artery calcification represents a major multi-ancestry effort identifying 121 loci, while facial morphology studies in Nature Communications reveal novel genetic architecture. Research shows strong emphasis on translational potential through druggable target identification.

Scientific collaborations span multiple international consortia as evidenced by large co-authorship networks in high-impact publications. The work shows particular strength in integrating diverse datasets across European and multi-ancestry populations.

Lu actively contributes to methodological development in genetic epidemiology, particularly in variance explanation frameworks and causal inference models. Current research directions include expanding multi-ancestry datasets and translating genetic findings into clinical applications for cardiovascular and skeletal disorders.