Haley Wyatt

Haley Wyatt is a Professor in the Department of Biochemistry at the University of Toronto. Her research focuses on the structure, function, and regulation of nucleases, which are critical enzymes in DNA repair and genome stability. She has made significant contributions to understanding the SLX4 protein's role in DNA repair complexes and developed the first biochemical assay for studying hTERT interactions with telomeric DNA.

• PhD in Biochemistry (2009), supervised by Tara Beattie at the University of Calgary.
• Postdoctoral work (2009-2017) at the Francis Crick Institute, London, on DNA repair mechanisms in Fanconi anemia.

Research Interests:
Wyatt's work centers on structure-selective endonucleases (SSEs) like SLX1-SLX4, MUS81-EME1, and XPF-ERCC1. These enzymes are vital for resolving toxic DNA structures during repair and replication. Her lab employs biochemistry, molecular biology, proteomics, and microscopy to study how dysregulation of these complexes contributes to genome instability and diseases such as cancer.

Scientific Awards & Grants:
She holds multiple prestigious grants and awards, including the NSERC Discovery Grant, CIHR Project Grant, and Canada Research Chair in Mechanisms of Genome Instability. Her work is supported by the Canadian Foundation for Innovation and Ontario Ministry of Research, Innovation and Science Fund.

Advising & Training:
The Wyatt lab offers research opportunities for graduate students in biochemistry and molecular biology. She teaches advanced courses like BCH473Y Advanced Research Project in Biochemistry and contributes to scientific skill development through BCH2101H.