Gönül Yapar

Gönül Yapar serves as an Assistant Professor (Doktor Öğretim Üyesi) in the Department of Chemistry at Istanbul Technical University, Turkey, actively contributing to both academic instruction and cutting-edge research in chemical sciences.

Her research program centers on Medicinal Chemistry and Organic Synthesis, with specialized expertise in designing Schiff base derivatives and heterocyclic compounds. She rigorously investigates their biological activities—including enzyme inhibition, antioxidant effects, and antimicrobial properties—as well as their chromogenic and optical sensing capabilities for anion detection, leveraging UV-VIS spectroscopy and fluorescence techniques.

Analysis of her 2023-2025 publications reveals a cohesive research trajectory focused on structure-activity relationships in bioactive molecules. Key trends include developing tumor-targeted carbonic anhydrase inhibitors for cancer therapy, engineering colorimetric sensors with tunable electron-donor groups, and optimizing ureido-benzenesulfonamide hybrids for dual-action inhibition against diabetic complications and neurodegenerative disorders.

Dr. Yapar currently supervises 2 research projects and leads 5 funded initiatives, including the 2025 synthesis of piperidine/pyrrolidine podant macrocycles, urea-based sulfapyridines for cholinesterase modulation (2024-2025), and diazo-coumarin hybrids targeting carbonic anhydrase isoforms IX/XII (2022-2023).