Guy Jacobs

Guy Jacobs is a Research Fellow at the University of Cambridge, Department of Archaeology, specializing in evolutionary genetics and microbiome ecology. His work combines large-scale genomic datasets with computational modeling to investigate human evolutionary history, archaic hominin interactions, and microbiome dynamics during subsistence transitions in traditionally hunter-gatherer communities across India and Indonesia.

• Primary focus on population genetics, human adaptation, and social network impacts
• Expertise in computational modeling of evolutionary processes
• Collaborations with C-CLEAR DTP and CREATES partnerships

Research spans ancient DNA analysis, archaic introgression patterns, and the interplay between genetic ancestry, environment, and health outcomes. Key projects include studies of Denisovan ancestry in Island Southeast Asia, microbiome differentiation in lifestyle transitions, and sociocultural influences on genetic diversity.

Recent publications highlight trends in human adaptation to malaria and high-altitude environments, microbiome evolution during urbanization, and computational methods for detecting selective sweeps. His work integrates genomic data with social and environmental variables to address questions in biological diversity and human phenotypic variation.

As part of the Cambridge NERC Doctoral Landscape Awards, he supervises students on topics ranging from archaic introgression analysis to genetic disease mapping. He utilizes datasets from Indonesia, India, and the Indonesian archipelago, combining genetic, transcriptomic, and mobility data in his research.