Guillaume Bouvier

Guillaume Bouvier is a Researcher at the Institut Pasteur in Paris, France. His work focuses on structural biology, computational modeling, and biophysics, particularly on protein conformational dynamics and drug-target interactions.

His research involves:

• Developing dimensionality reduction techniques for protein structural analysis
• Applying Self-Organizing Maps (SOM) to map protein conformational spaces
• Combining molecular dynamics simulations with experimental data
• Contributing to drug discovery projects targeting tuberculosis and viral diseases
• Working on algorithms for contact matrix ordering and protein fold prediction

Recent publications highlight his contributions to:

• 3D deep learning models for functional binding site prediction (InDeep/InDeepNet)
• Antiviral compound mechanism studies, particularly phthalazinone derivatives
• Atomic modeling of protein complexes using cryo-EM and co-evolutionary data
• Crosslinking mass spectrometry-based assembly modeling (XL-MOD software)
• Structural characterization of bacterial surface proteins and drug engagement