Gretchen Diehl

Gretchen Diehl is an Associate Professor at Weill Cornell Medicine's Graduate School of Medical Sciences, affiliated with the Immunology & Microbial Pathogenesis program. Her research focuses on the interplay between the intestinal microbiota, dietary factors, and immune regulation, aiming to understand molecular pathways that maintain intestinal homeostasis and their disruption in inflammatory diseases like IBD and colorectal cancer.

Research Interests:

• Immune calibration in response to dietary and microbial signals
• Distinction between commensal and pathogenic microbial responses
• Role of microbiota in innate immune activation and barrier repair
• Development and function of microbiota-specific T cells
• Epithelial-microbiota interactions

Publications highlight her work on microbiota-driven immune mechanisms in intestinal health and disease, including studies on macrophage IL-10 secretion, high-fat diet effects, and CX3CR1+ phagocyte regulation of T cell responses.

Labs and Teams: The Diehl Lab at Memorial Sloan Kettering Cancer Center collaborates with the Gerstner Sloan Kettering Graduate School of Biomedical Sciences, employing interdisciplinary techniques to study host-microbial interactions in immunity.